TUPELO, Miss.—This city of about 38,000 in the northeast part of Mississippi highlights the challenges facing the South’s least populous state. Tupelo offers a charming downtown, tourist attractions and a low cost of living. It has an active local economic-development and job-training effort and is close to large state universities.
Yet even this place, far better off than other parts of the state—and a steady draw for tourists as the birthplace of Elvis Presley—is struggling to attract and retain workers. The area has lost population in recent years.


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